Over the Hedge by T Lewis and Michael Fry for October 22, 2014
Transcript:
rj: If spider man had a baby, would it have spider skills? tree: not unless it was also bitten by a radioactive spider. rj: But spider-man's DNA was changed by the bite...that dna would be transferred to his kid! verne: RJ, what does DNA stand for? rJ: "durable naked aliens"... verne: Just checking. rj: you didn't think I knew that!....everyone knows that! tree: excuse me while I go dormant now.
Of course, Marvel already answered that question, ages ago:
http://marvel.wikia.com/May_Parker_(Earth-982)